Propylene Glycol In Electronic Cigarettes
Big scary word right? Propylene Glycol sounds like something that you would put in a rocket ship or race car. (PG) is a colorless, odorless liquid which is recognized and is protected by the U.S. Food and Drug Administration (FDA).Oddly enough it is the main ingredient in most electronic cigarette liquid .The FDA allows it for use as a direct food additive and it is approved by the U.S. FDA for certain indirect food additive utilizes. PG is used in cosmetics and in pharmaceuticals. PG features a wide range of practical applications including (this is why everyone is afraid) anti freezes ,that also includes water; heat transfer and hydraulic fluids; solvents,but also food; flavors and fragrances; cosmetics and private care products; pharmaceuticals; chemical intermediates; plasticizers; and thermoset plastic formulations. So here is the kicker.PG is not acutely toxic (single dose, high exposure). It’s essentially non-irritating for the skin and mildly irritating towards the eyes. Quite a few studies show that PG is just not a skin sensitizer or even a carcinogen.four Occupational and consumer exposure is possible since PG is used in a assortment of consumer items including toothpaste!. PG is not volatile and is miscible with water. It’s not expected to bio-accumulate and it’s not acutely toxic to water organisms except at really high concentrations.
Determining the safety of employing the vapors of propylene glycol and triethylene glycol in atmospheres inhabited by human beings, monkeys(don’t worry no one got hurt) and rats had been exposed continuously to high concentrations of those vapors for periods of 12 to 18 months. Equal numbers of managed animals were maintained under physically equivalent conditions. Extended term tests of the effects on ingesting triethylene glycol had been also carried out. The doses administered represented 50 to 700 times the quantity of glycol the animal could absorb by breathing air saturated with the glycol.
Comparative observations on the growth rates, blood counts, urine examinations, kidney function tests, fertility and common condition in the test and manage groups, exhibited no important differences between them with all the exception that the rats within the glycol atmospheres exhibited consistently larger weight gains. Some drying from the skin from the monkeys’ faces occurred immediately after many months continuous exposure to a heavy fog of triethylene glycol. However, when the vapor concentration was maintained just beneath saturation by implies from the glycostat this effect didn’t happen.
Examination at autopsy likewise failed to reveal any differences amongst the animals kept in glycolized air and these living within the ordinary room atmosphere. Extensive studies from the lungs was made to ascertain whether the glycol had created any generalized or nearby irritation. None was found. The kidneys, liver, spleen and bone marrow also were regular.
The results of these experiments in conjunction with the absence of any observed ill effects in patients exposed to each triethylene glycol and propylene glycol vapors for months at a time, give assurance that air containing these vapors in amounts up to the saturation point is completely harmless:)